VentriNova Founder: Hina W. Chaudhry, MD
Dr. Chaudhry’s research program focuses on cardiac regeneration, encompassing cell cycle regulation of cardiomyocytes and stem cell biology. The Chaudhry laboratory has characterized a critical role for cyclin A2 in mediating cardiomyocyte mitoses even after birth when expressed in the heart of transgenic mice. After a myocardial infarction (MI) is induced, these mice were able to repair their hearts with significantly restored cardiac function. There is molecular and cellular evidence of “de novo” cardiogenesis. As a translational strategy, the laboratory has delivered cyclin A2 cDNA in an adenoviral vector to adult, genetically naive rat and porcine hearts after MI, and observed significant restoration of cardiac function with evidence of cardiomyocyte proliferation. Cellular mechanistic data obtained in vitro utilizing isolated porcine cardiomyocytes demonstrated clear induction of cell division even in adult, fully differentiated cardiomyocytes. Given the significant efficacy of cardiac repair in a large animal model that mimics human cardiac anatomy and physiology, a human clinical trial utilizing this therapeutic strategy is being planned.
- Associate Professor of Medicine and Director of Cardiovascular Regenerative Medicine at Mount Sinai School of Medicine, New York.
- Florence Irving Assistant Professor of Medicine at Columbia University, New York.
- B.S. in Chemistry- MIT
- B.S. in Biology- MIT
- M.D. with Honors- Harvard Medical School
- Internal Medicine Residency- Duke University Medical Center
- Cardiology Fellowship- Hospital of the University of Pennsylvania
- American Heart Association Clinician-Scientist Award
- National Institutes of Health Research Career Award
- Irving Scholar Award-Columbia University
- Astrazeneca Cardiovascular Young Investigator Prize x2
- Sitara Imtiaz (Medal of Excellence, Gov’t of Pakistan)
- Chair of Harvard Medical School Class Reunion Committee
- Best Manuscript Award 2012 at American Heart Association
- Expert Commentator on Cardiovascular Disease for CNN
- TEDMED 2013 Innovation Scholar
Shapiro S, Ranjan A, Kawasake Y, Cheng RK, Kara RJ, Bhattacharya R, Sanz J, Garcia M, Chaudhry HW: Cyclin A2 Effects Cardiac Repair and Prevents Ischemic Heart Failure in Porcine Infarct Model, in submission.
Bolli P, Vardagrasso C, Bernstein E, Chaudhry HW: Chromatin Immunoprecipitation Of Adult Murine Cardiomyocytes. Current Protocols of Cell Biology, 2013 Mar;Chapter 17:Unit17.14.
Bolli P, Chaudhry HW: Molecular Physiology of Cardiac Regeneration. Annals of the NY Academy of Science, 2010 Nov; (1211):113-26.
Cheng RK, Asai T, Tang H, Dashoush NH, Kara RJ, Costa KD, Naka Y, Wu EX, Wolgemuth DJ, Chaudhry HW: Cyclin A2 Promotes Cardiac Regeneration after Myocardial Infarction and Prevents Heart Failure. Circulation Research, 2007 Jun 22;100(12):1741-8. original article and cover figure.
Woo YJ, Panlilio CM, Cheng RK, Liao GP, Suarez EE, Atluri P, Chaudhry HW: Myocardial Regeneration Therapy for Ischemic Cardiomyopathy with Cyclin A2. Journal of Thoracic and Cardiovascular Surgery, 2007 Apr; 133(4): 927-33.
Woo YJ, Panlilio CM, Cheng RK, Liao GP, Atluri P, Cohen JE, Chaudhry HW: Therapeutic Delivery of Cyclin A2 Induces Myocardial Regeneration and Enhances Cardiac Function in Ischemic Heart Failure. Circulation, 2006;114:I-206 – I-213.
Chaudhry HW, Dashoush N, Tang H, Zhang L, Wang X, Wu EX, Wolgemuth DJ: Cyclin A2 Mediates Cardiomyocyte Mitosis in the Postmitotic Myocardium. Journal of Biological Chemistry, Aug 20 2004; 279 (34): 35858-35866.